1. 제 목 : Microfluidic Technologies and Engineering of Cellular Microenvironments

2. 연 사 : Prof. Shuichi Takayama (Univ. of Michigan)

3. 일 시 : 2010년 3월 19일 (금) 16:30-17:30

4. 장 소 : 301동 105호

5. 연사약력 :
Shuichi Takayama is Associate Professor in the Department of Biomedical Engineering and the Macromolecular Science and Engineering Program at the University of Michigan. He is also a WCU Professor at Ulsan National Institute of Science and Technology (UNIST). He received his B.S. and M.S. from the University of Tokyo in 1994, his Ph.D. degree in chemistry and chemical biology from the Scripps Research Institute in 1998, and did postdoctoral studies at Harvard University. His research interest is in study of cells using Micro/Nanofluidics and Biomaterials & Surface Engineering. Honors include Leukemia and Lymphoma Society Fellow, The Ralph E. Powe Junior Faculty Award, The NSF Career Award, The Collegiate Inventors Competition Award, and
the College of Engineering Award for Research Excellence.

6. 내용요약 :
The gap between the cellular microenvironment in vivo and in vitro poses challenges for obtaining physiologically relevant responses from cells used in basic biological studies or for drawing out the maximum functional potential from cells used therapeutically. One of the reasons for this gap is because the fluidic environment of mammalian cells in vivo is microscale and dynamic whereas typical in vitro cultures are macroscopic and static. This presentation will give an overview of efforts in our laboratory to develop microfluidic systems that enable spatio-temporal control of both the chemical and fluid mechanical environment of cells. The technologies and methods close the physiology gap to provide biological information otherwise difficult to obtain. Specific technological topics that will be discussed include development of compartmentalized microfluidic devices, computerized microfluidics, self-controlled microfluidic systems, micropatterning using aqueous two-phase systems, and tunable nanochannels. Biological topics to be presented include application of the technologies to study lung disease, treat infertility, model sepsis (blood infection), engineering of stem cell niches, analysis of cell
signaling, and single molecule DNA and chromatin analysis.

7. 문 의 : 기계항공공학부 방현우 교수 (☏ 880-1722