1. 제 목 : Rapid Directed Evolution of Molecules in Microfluidic Systems

2. 연 사 : Prof. H. Tom Soh (University of California Santa Barbara)

3. 일 시 : 2011년 9월 2일 (금) 16:30-17:30

4. 장 소 : 301동 105호

5. 연사약력 :

Dr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University, and Ph.D. in Electrical Engineering from Stanford University. Prior to joining UCSB in 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and MEMS R&D group at Agere Systems.

6. 내용 :

Current techniques in high performance molecular and cellular separations are limited by the inherent coupling among three competing parameters: throughput, purity, and recovery of rare species.Our group utilizes unique advantages of microfluidics technology to decouple these competing parameters by precise and reproducible generation of separation forces that are not accessible in conventional, macroscopic systems.In this seminar, we will first discuss novel high performance electrokinetic, magnetophoretic and acoustophoretic separation systems to purify rare target cells from complex mixtures.Next, we will present our recent work in applying the microfluidic separation systems for Rapid Directed Evolution of molecules (RDE).We will provide theoretical and experimental evidence for extremely fast generation of affinity reagents molecular recognition elements that bind to target molecules with high affinity and specificity.Finally, we will present innovative methods of evolving molecular machines that are capable of performing complex functions, including binding induced switching and conformation change.


7. 문 의 : 기계항공공학부 이동준 교수 (djlee@snu.ac.kr)