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[열공학,정밀기계설계특강2] Lattice Boltzmann approach to the solution for the rheology of red blood cells
1. 제목 : Lattice Boltzmann approach to the solution for the rheology
of red blood cells
2. 일시 : 2008년 10월 17일(금) 16:30-17:30
3. 장소 : 서울대학교 301동 105호
4. 연사 : 이준상 교수(미시간 웨인주립대)
5. 연사약력 :
Dr. Joon Sang Lee is an Assistant Professor in the Department of Mechanical Engineering at Wayne State University (WSU) in Detroit, MI, USA. Prior to joining the faculty at WSU in 2004, he obtained B.S., M.S. and Ph.D. degrees in Mechanical Engineering from Iowa State University. Dr. Lee’s principal research activities focus on the development of numerical models to predict rheological behavior of multiphase flows in the area of biofluidics and micro/nano fluidics. Recent research efforts include the development of a non-invasive diagnosis method for arterial diseases using numerical assisted optical imaging and micro/nano systems for heat transfer augmentation. He was recently recognized with the Outstanding Research Award from Iowa State University and the nomination for Joseph B. Whitehead Educator of Distinction Award from Coca-Cola Scholars Program. Dr. Lee is a member of American Society of Mechanical Engineer and American Institute of Aeronautics and Astronautics.
6. 내용요약 : The dependence of the rheological properties of blood on shape, aggregation, and
deformability of red blood cells (RBCs) has been investigated by numerous researchers using
hybrid systems through coupling fluid with solid models. There are two basic hypotheses for
the explanation of the RBC deformability: One is based on the idea that the changing rigidity of the membrane is a function of the cytoskeleton constituent proteins remodeling, and therefore treat the spectrin chain as springs with bending and shearing elasticity. The other is based on the idea that the lipid bilayer is the major contributor to the RBC shape and deformability, due to its interaction with surface active substances contained in the surrounding plasma. The change in the lipid bilayer causes a change in the surface tension and the energetic balance between the attractive and repulsive interactions of the RBC membrane. Our model treats the RBC as an immiscible droplet in plasma, and the membrane as macro-colloid containing surfactant lipid molecules. The lipid molecule distribution on the RBC surface is non-homogeneous and therefore the resulting surface tension is non-isotropic. The rigidity of the RBC is controlled by our model surface tension parameter. This parameter is always changing based on the geometry and flow condition of the simulation frame. Steric repulsion is used to suppress coalescence. This repulsion is activated only when two RBCs are at predetermined proximity from each other. Our model produces a map containing the values of the surface tension parameter at variable zones on the interface, which could eventually be used for the interpretation of the cell rigidity based on any of the acceptable hypotheses mentioned above.
7. 문의 : 기계항공공학부 유정열 교수(☏ 880-7112)
of red blood cells
2. 일시 : 2008년 10월 17일(금) 16:30-17:30
3. 장소 : 서울대학교 301동 105호
4. 연사 : 이준상 교수(미시간 웨인주립대)
5. 연사약력 :
Dr. Joon Sang Lee is an Assistant Professor in the Department of Mechanical Engineering at Wayne State University (WSU) in Detroit, MI, USA. Prior to joining the faculty at WSU in 2004, he obtained B.S., M.S. and Ph.D. degrees in Mechanical Engineering from Iowa State University. Dr. Lee’s principal research activities focus on the development of numerical models to predict rheological behavior of multiphase flows in the area of biofluidics and micro/nano fluidics. Recent research efforts include the development of a non-invasive diagnosis method for arterial diseases using numerical assisted optical imaging and micro/nano systems for heat transfer augmentation. He was recently recognized with the Outstanding Research Award from Iowa State University and the nomination for Joseph B. Whitehead Educator of Distinction Award from Coca-Cola Scholars Program. Dr. Lee is a member of American Society of Mechanical Engineer and American Institute of Aeronautics and Astronautics.
6. 내용요약 : The dependence of the rheological properties of blood on shape, aggregation, and
deformability of red blood cells (RBCs) has been investigated by numerous researchers using
hybrid systems through coupling fluid with solid models. There are two basic hypotheses for
the explanation of the RBC deformability: One is based on the idea that the changing rigidity of the membrane is a function of the cytoskeleton constituent proteins remodeling, and therefore treat the spectrin chain as springs with bending and shearing elasticity. The other is based on the idea that the lipid bilayer is the major contributor to the RBC shape and deformability, due to its interaction with surface active substances contained in the surrounding plasma. The change in the lipid bilayer causes a change in the surface tension and the energetic balance between the attractive and repulsive interactions of the RBC membrane. Our model treats the RBC as an immiscible droplet in plasma, and the membrane as macro-colloid containing surfactant lipid molecules. The lipid molecule distribution on the RBC surface is non-homogeneous and therefore the resulting surface tension is non-isotropic. The rigidity of the RBC is controlled by our model surface tension parameter. This parameter is always changing based on the geometry and flow condition of the simulation frame. Steric repulsion is used to suppress coalescence. This repulsion is activated only when two RBCs are at predetermined proximity from each other. Our model produces a map containing the values of the surface tension parameter at variable zones on the interface, which could eventually be used for the interpretation of the cell rigidity based on any of the acceptable hypotheses mentioned above.
7. 문의 : 기계항공공학부 유정열 교수(☏ 880-7112)