11월 30일(화) 세미나가 다음과 같이 추가되었습니다.

세미나 장소는 301동 1512호입니다.

=========================================================================================
1. 제 목 : Hemorheological Approach to Vulnerable Plaques
(급성심근경색을 일으키는 vulnerable 혈전에 대한 혈유변학적 접근)

2. 연 사 : Prof. 조영일
(Department of Mechanical Eng. & Mechanics, Drexel University)

3. 일 시 : 2010년 11월 30일 (화) 14:00-15:15 pm

4. 장 소 : 301동 1512호 세미나실

5. 연사약력 :
EDUCATION:
Ph.D. -1980, Mechanical Engineering, University of Illinois, Chicago
M.S. -1977, Mechanical Engineering, University of Illinois, Chicago
B.S. -1972, Mechanical Engineering, Seoul National University, Korea

Professor Cho's research interest includes hemorheology and water treatment using plasma discharge. Professor Cho has authored/co-authored approximately 200 papers in the area of biofluid mechanics, rheology, and energy. He is an editor for Handbook of Heat Transfer (McGraw Hill) and the Advances in Heat Transfer (Academic Press). He was the recipient of the 1992 Lindback Award for excellence in teaching at Drexel University. In 1995, he was the recipient of the Research Professor of the Year at Drexel University. Prior to joining Drexel, he worked at Jet Propulsion Laboratory (NASA), California Institute of Technology, Pasadena, CA, conducting experimental and analytical investigations in the area of biofluid mechanics, heat transfer, and acoustics.

6. 내용 요약
Two main components in hemorheology are shear stress and blood viscosity. The shear stress is mathematically defined as the product of blood viscosity and shear rate. The two main parameters that affect blood viscosity include hematocrit and plasma proteins. Both shear rate and shear stress stimulate a number of biochemical processes that affect the initiation and progression of atherosclerosis as well as plaque rupture and erosion, indicating the significance of the hemorheological interaction between moving blood and vascular wall in the diagnosis and treatment of vascular diseases.
The vulnerable plaque that can lead to arterial thrombotic events is the one with a high risk of plaque rupture and erosion. One of the most commonly accepted causes of the rupture is the shear stress. Even at a subclinical plaque, the shear stress can increase to a large value beyond 300 dyne/cm2 (i.e., a value that can cause endothelial damage) at the proximal side of the plaque, causing plaque rupture. The distal side of the plaque is characterized by a disturbed flow with low wall shear stress and increased endothelial cell apoptosis. Hence the distal side becomes the site of both plaque growth and erosion. In addition, the activity of matrix metalloproteinase-9 at the distal region is found to increase due to the oscillating low shear stress, further increasing the plaque erosion risk.
Also, shear stress is the main parameter that produces microparticles from both endothelial cells and platelets. The production of such microparticles is related to not only shear stress but also shear rate. Platelet microparticles are reported to increase the risk of thrombosis at small vessels distal to plaque.
Furthermore, the relationship between hyperviscosity and poor oxygen delivery will be discussed in the context of the mortality risk factor in the coronary heart disease. Other clinical manifestations of hyperviscosity will be presented, including diabetic foot ulcer, blood viscosity surge after hemodialysis, cerebral infarction, hemorrhagic stroke, etc.

7. 문 의 : 기계항공공학부 유정열 교수(☏ 7112), 송한호 교수 (☏ 1651)