1. 제 목 : Microfabricated platforms to interrogate T cell dynamics
2. 연 사 : 도 준 상 교수(POSTECH)
3. 일 시 : 2011년 12월 2일 (금) 16:30-17:30
4. 장 소 : 301동 105호
5. 연사약력 :
(EDUCATION)
-Ph.D. Department of Chemical Engineering / Program in Polymer Science and Technology,
Massachusetts Institute of Technology (9/2001 ~ 6/2006).
-B.S. Department of Chemical Engineering, Seoul National University (3/1995 ~ 2/1999)
(PROFESSIONAL CAREER)
-Assistant Professor, IBB, Pohang University of Science and Technology (7/2010 ~ present).
-Assistant Professor, I-Bio/Department of Mechanical Engineering, Pohang University of
Science and Technology (2/2008 ~ present).
-Postdoctoral Researcher, Department of Pathology, University of California at San Francisco
(9/2006 ~ 1/2008).
-Postdoctoral Researcher, Department of Materials Science and Engineering, Massachusetts
Institute of Technology (6/2006 ~ 8/2006).
6. 내용 :
T cells orchestrate antigen-specific immune responses against wide variety of foreign
pathogens. Many immune-related diseases have close relationship with malfunction of
T cells, thus understanding the dynamics of T cells under various physiological/
pathological circumstances is essential for the rational design of therapeutics against
the diseases. In vitro microfabricated platforms can provide many exciting opportunities
to investigate molecular and cellular dynamics of T cells. In this presentation, I am going
to show three examples of how microfabricated platforms are developed and utilized
to address fundamental questions in T cell biology: (1) T cell-antigen presenting cell pair
arrays fabricated using a bio-friendly photoresist polymer for the study of the molecular
dynamics in immunological synapses, (2) Cell-laden hydrogel microwells for the study of
multi-cellularity of activating T cells, and (3) Nanostructured surfaces fabricated by
UV-assisted capillary force lithography for the study of directional migration of T cells.
7. 문 의 : 기계항공공학부 이동준 교수 (djlee@snu.ac.kr)